Embryonic regionalization of the neocortex
نویسندگان
چکیده
Understanding the development of the vertebrate brain and in particular that of the neocortex, where high brain functions reside, remains one of the most difficult and exciting tasks in biology. In this review, we discuss recent experimental evidence as well as different possibilities for the intrinsic regionalization of the embryonic dorsal telencephalon, which may be related to the formation of distinct functional areas in the adult neocortex.
منابع مشابه
COUP-TFI: an intrinsic factor for early regionalization of the neocortex.
Regionalization of the cerebral cortex is thought to involve two phases: an early regionalization phase and a later refinement phase. It has been shown that early regionalization of the neocortex does not require thalamic inputs and is regulated by intrinsic factors. Recently, two such intrinsic factors, Pax6 and Emx2, have been identified. In this study, we identified COUP-TFI as a regulatory ...
متن کاملMolecular regionalization of the neocortex is disrupted in Fgf8 hypomorphic mutants.
The neocortex is divided into multiple areas with specific architecture, molecular identity and pattern of connectivity with the dorsal thalamus. Gradients of transcription factor expression in the cortical primordium regulate molecular regionalization and potentially the patterning of thalamic projections. We show that reduction of Fgf8 levels in hypomorphic mouse mutants shifts early gradient...
متن کاملGenetic control of cortical regionalization and connectivity.
Herein, the genetic control of regionalization and connectivity of the neocortex are reviewed. Evidence is accumulating which suggests that intrinsic mechanisms have a central role in controlling cortical regional specification and differentiation. Expression patterns of several genes (Id-2, Tbr-1, cadherin-6, cadherin-8, neuropilin-2, Wnt-7b, Eph-A7 and RZR-beta) are described; the expressions...
متن کاملThe early topography of thalamocortical projections is shifted in Ebf1 and Dlx1/2 mutant mice.
The prevailing model to explain the formation of topographic projections in the nervous system stipulates that this process is governed by information located within the projecting and targeted structures. In mammals, different thalamic nuclei establish highly ordered projections with specific neocortical domains and the mechanisms controlling the initial topography of these projections remain ...
متن کاملThe signs of aphasia
Much debate in 19th century neurology centered around the question of whether there is functional specialization within the neocortex. Today, this is no longer a contentious issue: functional specialization in the adult neocortex is well established. Nonetheless, a form of this old debate rages on in research on neocortical development. At issue is whether neocortical regionalization arises fro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Mechanisms of Development
دوره 107 شماره
صفحات -
تاریخ انتشار 2001